Guardians vs. Tigers Betting Odds, Free Picks, and Predictions - 6:40 PM ET (Thu, May 22, 2025)

Wed, May 21, 2025
MLB News (CapperTek)

The Cleveland Guardians travel to the Detroit Tigers in MLB Baseball action on Thursday, May 22, 2025. First pitch is set for 6:40 PM ET.

Thinking about betting on this game? You've found the right article! We at CapperTek have all the latest sports betting tools and information to help put you on the right side of the betting action for this match-up.

Guardians vs. Tigers Game Info and Betting Odds

Away Team: Cleveland Guardians (Underdog)
Home Team: Detroit Tigers (Favorite)
Date: Thursday, May 22, 2025
Time: 6:40 PM ET
League: Major League Baseball (MLB)

Cleveland Guardians Moneyline: +117
Detroit Tigers Moneyline: -130

Cleveland Guardians Run Line: +1.5 (-188)
Detroit Tigers Run Line: -1.5 (+163)

Game Total Runs: 8 (Over +100 / Under -115)

Betting odds provided by Premium Picks. Visit PremiumPicks.com.com today and check out their unique wagering system that will help you beat the books! Odds and lines are the best available at the time of publishing and are subject to change.

A Deeper Look Inside the Betting Numbers

We here at CapperTek provide in-depth betting trends for both the Cleveland Guardians and the Detroit Tigers, but let's take a deeper look inside some of the betting numbers for this match-up right now.

Let's start off by breaking down the away team and +117 betting underdogs, the Cleveland Guardians.

In their last 10 games, the Guardians have a Straight Up record of 4 wins, 6 losses and an active Straight Up streak of 1 win in a row. Also in their last 10 games, the Guardians have an Against-the-Spread record of 4 wins, 6 losses and an active Against-the-Spread streak of 1 win in a row. The Game Total Runs results for Guardians games have a record of 1 over, 8 unders, 1 pushes in their last 10 games with an active streak of 4 unders in a row.

Now let's break down the home team and -130 betting favorites, the Detroit Tigers.

In their last 10 games, the Tigers have a Straight Up record of 7 wins, 3 losses and an active Straight Up streak of 2 wins in a row. Also in their last 10 games, the Tigers have an Against-the-Spread record of 3 wins, 7 losses and an active Against-the-Spread streak of 1 win in a row. The Game Total Runs results for Tigers games have a record of 5 overs, 3 unders, 2 pushes in their last 10 games with an active streak of 1 under in a row.

If you need more detailed betting information for this match-up such as the trends or steaks broken down into Home vs. Away splits, or Favorite vs. Underdog splits, make sure to check out the Guardians vs. Tigers Trend Finder directly.

Who's Going to Win This Game? Our Prediction

We pride ourselves here at CapperTek on providing our users with the most advanced machine learning artificial intelligence to simulate game outcomes using algorithms we have custom designed over 10+ years of research and development.

Based on our simulation of the Guardians vs. Tigers MLB game, we have the Cleveland Guardians beating the Detroit Tigers with a simulated final score of: Cleveland Guardians [4] - Detroit Tigers [3]

Sometimes our game simulations change, like if there's a major line movement, drastic shift in the odds, or if there's a key injury, etc. To make sure you have the latest and most accurate simulation, you can run the Guardians vs. Tigers Simulation directly. Also after the Guardians vs. Tigers game is finished, you can re-run the simulation and check out how the simulated final result did compared to the actual final result.

What Should I Bet On? Our Free Picks

OK let's get down to the real reason you're here, who or what should you bet on in the Guardians vs. Tigers MLB match-up? Based on the simulated prediction and results for this match-up above, we here at CapperTek suggest you place the following bets:

Free Moneyline Pick: Guardians +117

Free Run Line Pick: Guardians +1.5 (-188)

Free Total Pick: Under 8 (-115)

Hopefully our free picks and predictions help you out if you're wagering on the Cleveland Guardians vs. Detroit Tigers MLB Baseball match-up. Our betting tips are based on detailed analytics and wagering intelligence to provide you the best possible plays. Our goal is to provide valuable sports betting information to gamblers and help put them on the right side of the action.

Please remember to always wager responsibly. For problem gambling help, please visit the National Council on Problem Gambling.

This article was generated using CapperTek's Betelligence Publisher API. Learn more.