The Week 3 NFL schedule features a plethora of mouthwatering matchups, including division rivalries like Bills vs. Dolphins, Eagles vs. Commanders and Cowboys vs. Giants. Division rivalries are often tough to predict in the NFL given the familiarity of both teams, but it will be especially difficult in Week 3. According to the latest Week 3 NFL odds from Caesars Sportsbook, the Giants are one-point favorites against the Cowboys at home. Dallas has dominated its NFC East rivals over the years, beating New York in nine of the last 10 meetings. The Bills, meanwhile, enter their division rivalry against the Dolphins as 5.5-point favorites on the road in the current NFL spreads. All of the Week 3 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 3 NFL picks now.'
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of AP Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 3 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.
One of the model's strongest Week 3 NFL picks is that the Bengals (-6) go on the road and cover against the Jets. After making a remarkable run to the Super Bowl last season, the Bengals are looking to avoid a disastrous 0-3 start. Quarterback Joe Burrow has been sacked 13 times through the first two games, but Cincinnati's offense enters Sunday's matchup averaging 232 passing yards and 111 rushing yards per game. The Jets, meanwhile, are giving up 27 points per game, which ranks 25th in the league. Plus, the Jets are 1-5 against the spread in their last six games following a straight-up win, which bodes well for Cincinnati.
SportsLine's model expects Burrow to throw for 300 yards on Sunday, helping the Bengals cover the spread in almost 60% of simulations. The Over (45) also has value since it hits nearly 60% of the time.
Another one of the model's Week 3 NFL predictions: The Seahawks (-1) cover the spread at home versus the Falcons. Geno Smith may not be the long-term answer at QB for the Seahawks, but he is the short-term solution. He has gone an astounding 9-1 against the spread over his last 10 starts, with a 13:2 touchdown-to-interception ratio over that span. His 81% completion percentage leads the NFL this season and is nearly 20 points higher than Marcus Mariota's.
The model has Smith playing a more efficient game than Mariota and the Seahawks putting up over 130 yards on the ground by averaging over five yards per carry. With that, Seattle is projected to cover as a 2-point favorite in well over 50 percent of simulations, with the Over (42) hitting over 50 percent of the time.'See which other teams to pick here.
The model has also made the call on who wins and covers in every other game on the Week 3 NFL schedule, and it's calling for a Super Bowl contender to go down hard.'You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,000 since its inception, and find out.
Get full NFL picks at SportsLine
Sunday, Sept. 25
Chiefs at Colts (+5.5, 50.5)
Indianapolis Colts vs. Kansas City Chiefs
Moneyline
Spread
Total
IND
+205
BET NOW
+5.5
-110
BET NOW
o50.5
-110
BET NOW
KC
-250
BET NOW
-5.5
-110
BET NOW
u50.5
-110
BET NOW
Ravens at Patriots (+3, 44)
New England Patriots vs. Baltimore Ravens
Moneyline
Spread
Total
NE
+130
BET NOW
+3
-120
BET NOW
o44
-110
BET NOW
BAL
-155
BET NOW
-3
+100
BET NOW
u44
-110
BET NOW
Saints at Panthers (+2.5, 41)
Carolina Panthers vs. New Orleans Saints
Moneyline
Spread
Total
CAR
+118
BET NOW
+2.5
+100
BET NOW
o41
-110
BET NOW
NO
-140
BET NOW
-2.5
-120
BET NOW
u41
-110
BET NOW
Texans at Bears (-2.5, 40)
Chicago Bears vs. Houston Texans
Moneyline
Spread
Total
CHI
-145
BET NOW
-2.5
-120
BET NOW
o40
-110
BET NOW
HOU
+122
BET NOW
+2.5
+100
BET NOW
u40
-110
BET NOW
Bills at Dolphins (+5.5, 52.5)
Miami Dolphins vs. Buffalo Bills
Moneyline
Spread
Total
MIA
+185
BET NOW
+5.5
-110
BET NOW
o52.5
-110
BET NOW
BUF
-225
BET NOW
-5.5
-110
BET NOW
u52.5
-110
BET NOW
Lions at Vikings (-6, 52.5)
Minnesota Vikings vs. Detroit Lions
Moneyline
Spread
Total
MIN
-250
BET NOW
-6
-110
BET NOW
o52.5
-110
BET NOW
DET
+205
BET NOW
+6
-110
BET NOW
u52.5
-110
BET NOW
Bengals at Jets (+6, 45)
New York Jets vs. Cincinnati Bengals
Moneyline
Spread
Total
NYJ
+205
BET NOW
+6
-110
BET NOW
o45
-110
BET NOW
CIN
-250
BET NOW
-6
-110
BET NOW
u45
-110
BET NOW
Raiders at Titans (+2, 45.5)
Tennessee Titans vs. Las Vegas Raiders
Moneyline
Spread
Total
TEN
+110
BET NOW
+2
-110
BET NOW
o45.5
-110
BET NOW
LV
-130
BET NOW
-2
-110
BET NOW
u45.5
-110
BET NOW
Eagles at Commanders (+6.5, 47)
Washington Commanders vs. Philadelphia Eagles
Moneyline
Spread
Total
WAS
+235
BET NOW
+6.5
-110
BET NOW
o47
-110
BET NOW
PHI
-292
BET NOW
-6.5
-110
BET NOW
u47
-110
BET NOW
Jaguars at Chargers (-7, 47)
Los Angeles Chargers vs. Jacksonville Jaguars
Moneyline
Spread
Total
LAC
-335
BET NOW
-7
-110
BET NOW
o47
-105
BET NOW
JAC
+260
BET NOW
+7
-110
BET NOW
u47
-115
BET NOW
Packers at Buccaneers (PK, 42)
Tampa Bay Buccaneers vs. Green Bay Packers
Moneyline
Spread
Total
TB
-110
BET NOW
PK
-110
BET NOW
o42
-110
BET NOW
GB
-110
BET NOW
PK
-110
BET NOW
u42
-110
BET NOW
Rams at Cardinals (+3.5, 48.5)
Arizona Cardinals vs. Los Angeles Rams
Moneyline
Spread
Total
ARI
+158
BET NOW
+3.5
-110
BET NOW
o48.5
-110
BET NOW
LAR
-190
BET NOW
-3.5
-110
BET NOW
u48.5
-110
BET NOW
Falcons at Seahawks (-1, 42)
Seattle Seahawks vs. Atlanta Falcons
Moneyline
Spread
Total
SEA
-115
BET NOW
-1
-110
BET NOW
o42
-110
BET NOW
ATL
-105
BET NOW
+1
-110
BET NOW
u42
-110
BET NOW
49ers at Broncos (+1.5, 45)
Denver Broncos vs. San Francisco 49ers
Moneyline
Spread
Total
DEN
+105
BET NOW
+1.5
-110
BET NOW
o45
-110
BET NOW
SF
-125
BET NOW
-1.5
-110
BET NOW
u45
-110
BET NOW
Monday, Sept. 26
Cowboys at Giants (-1, 39)
New York Giants vs. Dallas Cowboys
Moneyline
Spread
Total
NYG
-115
BET NOW
-1
-110
BET NOW
o39
-110
BET NOW
DAL
-105
BET NOW
+1
-110
BET NOW
u39
-110
BET NOW