Mississippi State vs. South Carolina Pick Center

Mississippi State vs. South Carolina Betting Odds, Free Picks, and Predictions - 4:15 PM ET (Sat, Sep 19, 2026)

Mississippi State battle South Carolina in NCAA College Football action on Saturday, September 19, 2026. Kickoff is set for 4:15 PM ET.

Want betting info or a prediction for this game? You've found the right article! We at CapperTek have all the latest sports betting tools and information to help put you on the right side of the betting action for this match-up.

Mississippi State vs. South Carolina Game Info and Betting Odds

Away Team: Mississippi State (Underdog)
Home Team: South Carolina (Favorite)
Date: Saturday, September 19, 2026
Time: 4:15 PM ET
League: NCAA College Football (NCAAF)

Mississippi State Moneyline: +141
South Carolina Moneyline: -168

Mississippi State Spread: +3 (+100)
South Carolina Spread: -3 (-122)

Game Total Points: 58.5 (Over -113 / Under -113)

Betting odds provided by Premium Picks. Visit PremiumPicks.com today and check out their unique wagering system that will help you beat the books! Odds and lines are the best available at the time of publishing and are subject to change.

A Closer Look Inside the Betting Numbers

We here at CapperTek provide in-depth betting trends for both Mississippi State and South Carolina, but let's take a closer look inside some of the betting numbers for this match-up right now.

First let's break down the away team and +141 betting underdogs, Mississippi State.

In their last 10 games, Mississippi State has a Straight Up record of 3 wins, 7 losses and an active Straight Up streak of 2 wins in a row. Also in their last 10 games, Mississippi State has an Against-the-Spread record of 5 wins, 5 losses and an active Against-the-Spread streak of 2 wins in a row. The Game Total Points results for Mississippi State games has a record of 6 overs, 4 unders in their last 10 games with an active streak of 1 under in a row.

OK now let's break down the home team and -168 betting favorites, South Carolina.

In their last 10 games, South Carolina has a Straight Up record of 4 wins, 6 losses and an active Straight Up streak of 2 wins in a row. Also in their last 10 games, South Carolina has an Against-the-Spread record of 5 wins, 5 losses and an active Against-the-Spread streak of 1 loss in a row. The Game Total Points results for South Carolina games has a record of 5 overs, 5 unders in their last 10 games with an active streak of 1 under in a row.

If you you would like more detailed betting information for this match-up such as the trends or steaks broken down into Home vs. Away splits, or Favorite vs. Underdog splits, make sure to check out the Mississippi State vs. South Carolina Trend Finder directly.

Who's Going to Win This Game? Our Prediction

We pride ourselves here at CapperTek on providing our users with the most advanced machine learning artificial intelligence to simulate game outcomes using algorithms we have custom designed over 10+ years of research and development.

Based on our simulation of Mississippi State vs. South Carolina NCAAF game, we have South Carolina beating Mississippi State with a simulated final score of: Mississippi State [24] - South Carolina [26]

Sometimes our game simulations change, like if there's a major line movement, drastic shift in the odds, or if there's a key injury, etc. To make sure you have the latest and most accurate simulation, you can run the Mississippi State vs. South Carolina Simulation directly. Also after the Mississippi State vs. South Carolina game is finished, you can re-run the simulation and check out how the simulated final result did compared to the actual final result.

What Should I Bet On? Our Free Picks

Now let's get down to the real reason you're here, who or what should you bet on in the Mississippi State vs. South Carolina NCAAF match-up? Based on the simulated prediction and results for this match-up above, we here at CapperTek suggest you place the following bets:

Free Moneyline Pick: South Carolina -168

Free Spread Pick: Mississippi State +3 (+100)

Free Total Pick: Under 58.5 (-113)

We hope our free picks and predictions help you out if you're wagering on the Mississippi State vs. South Carolina NCAA College Football match-up. Our betting tips are based on detailed analytics and wagering intelligence to provide you the best possible plays. Our goal is to provide valuable sports betting information to gamblers and help put them on the right side of the action.

Please remember to always wager responsibly. For problem gambling help, please visit the National Council on Problem Gambling.

This article was generated using CapperTek's Betelligence Publisher API. Learn more.

Looking for More Picks?

You can browse all the individual handicapper picks below.

---

Mississippi State vs South Carolina Betting Odds, Free Picks, and Predictions (9/19/2026)

---

Mississippi State vs South Carolina Betting Trends (9/19/2026)

---

Mississippi State vs South Carolina Trend and Streak Finder (9/19/2026)

---

Mississippi State vs South Carolina Simulation and Prediction (9/19/2026)

---

Mississippi State vs South Carolina Handicapper Consensus Report (9/19/2026)

---

Mississippi State vs South Carolina Latest Betting News (9/19/2026)

---