Pittsburgh Steelers vs. Detroit Lions Pick Center

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SPREAD

TOTAL

Pittsburgh Steelers

+318

+7.5
(-103)

O 52
(-103)

Detroit Lions

-381

-7.5
(-109)

U 52
(-111)

NFL

FINAL (12/21/2025)

Steelers vs. Lions Betting Odds, Free Picks, and Predictions - 4:25 PM ET (Sun, Dec 21, 2025)

The Pittsburgh Steelers go up against the Detroit Lions in NFL Football action on Sunday, December 21, 2025. Kickoff is set for 4:25 PM ET.

Are you looking to bet on this game? You've found the right article! We at CapperTek have all the latest sports betting tools and information to help put you on the right side of the betting action for this match-up.

Steelers vs. Lions Game Details and Betting Odds

Away Team: Pittsburgh Steelers (Underdog)
Home Team: Detroit Lions (Favorite)
Date: Sunday, December 21, 2025
Time: 4:25 PM ET
League: National Football League (NFL)

Pittsburgh Steelers Moneyline: +254
Detroit Lions Moneyline: -307

Pittsburgh Steelers Spread: +7 (-119)
Detroit Lions Spread: -7 (+104)

Game Total Points: 50 (Over -107 / Under -109)

Betting odds provided by Premium Picks. Visit PremiumPicks.com today and check out their unique wagering system that will help you beat the books! Odds and lines are the best available at the time of publishing and are subject to change.

A Closer Look Inside the Betting Numbers

We here at CapperTek provide in-depth betting trends for both the Pittsburgh Steelers and the Detroit Lions, but let's take a closer look inside some of the betting numbers for this match-up right now.

First let's break down the away team and +254 betting underdogs, the Pittsburgh Steelers.

In their last 10 games, the Steelers have a Straight Up record of 5 wins, 5 losses and an active Straight Up streak of 2 wins in a row. Also in their last 10 games, the Steelers have an Against-the-Spread record of 5 wins, 5 losses and an active Against-the-Spread streak of 2 wins in a row. The Game Total Points results for Steelers games have a record of 4 overs, 6 unders in their last 10 games with an active streak of 1 under in a row.

OK now let's break down the home team and -307 betting favorites, the Detroit Lions.

In their last 10 games, the Lions have a Straight Up record of 5 wins, 5 losses and an active Straight Up streak of 1 loss in a row. Also in their last 10 games, the Lions have an Against-the-Spread record of 4 wins, 6 losses and an active Against-the-Spread streak of 1 loss in a row. The Game Total Points results for Lions games have a record of 7 overs, 3 unders in their last 10 games with an active streak of 4 overs in a row.

If you you would like more detailed betting information for this match-up such as the trends or steaks broken down into Home vs. Away splits, or Favorite vs. Underdog splits, make sure to check out the Steelers vs. Lions Trend Finder directly.

Who's Going to Win This Game? Our Prediction

We pride ourselves here at CapperTek on providing our users with the most advanced machine learning artificial intelligence to simulate game outcomes using algorithms we have custom designed over 10+ years of research and development.

According to our simulation of the Steelers vs. Lions NFL game, we have the Detroit Lions beating the Pittsburgh Steelers with a simulated final score of: Pittsburgh Steelers [26] - Detroit Lions [27]

Sometimes our game simulations change, like if there's a major line movement, drastic shift in the odds, or if there's a key injury, etc. To make sure you have the latest and most accurate simulation, you can run the Steelers vs. Lions Simulation directly. Also after the Steelers vs. Lions game is finished, you can re-run the simulation and check out how the simulated final result did compared to the actual final result.

What Should I Bet On? Our Free Picks

Now let's get down to the real reason you're here, who or what should you bet on in the Steelers vs. Lions NFL match-up? According to the simulated prediction and results for this match-up above, we here at CapperTek suggest you place the following bets:

Free Moneyline Pick: Lions -307

Free Spread Pick: Steelers +7 (-119)

Free Total Pick: Over 50 (-107)

We hope our free picks and predictions help you out if you're wagering on the Pittsburgh Steelers vs. Detroit Lions NFL Football match-up. Our betting tips are based on detailed analytics and wagering intelligence to provide you the best possible plays. Our goal is to provide valuable sports betting information to gamblers and help put them on the right side of the action.

Please remember to always wager responsibly. For problem gambling help, please visit the National Council on Problem Gambling.

This article was generated using CapperTek's Betelligence Publisher API. Learn more.