College football odds, picks, predictions, best bets for Week 4, 2022: Proven simulation likes USC, Texas

Fri, Sep 23, 2022

College football odds, picks, predictions, best bets for Week 4, 2022: Proven simulation likes USC, Texas

No. 5 Clemson will face its first real test of the season when it travels to No. 21 Wake Forest on Saturday afternoon. The Tigers have won all three of their games by at least 20 points, while Wake Forest is coming off consecutive wins over Vanderbilt and Liberty. Caesars Sportsbook has Clemson priced as a 7-point favorite in the latest Week 4 college football odds. Should you back the Tigers with your Week 4 college football bets?

Another top Week 4 college football matchup pits No. 11 Tennessee against No. 20 Florida in the 3:30 p.m. ET SEC on AP matchup. The Vols have never been favored by more than a touchdown against the Gators, but they are 10.5-point favorites in the latest Week 4 college football spreads. Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4'college football odds'from Caesars and locked in picks for every FBS matchup.'Head here to see every pick.

One of the college picks the model is high on in Week 4: No. 22 Texas (-7) goes on the road and covers against Texas Tech in a 3:30 p.m. ET matchup in Lubbock. The Longhorns have had a roller coaster last two weeks, but they have come away with positives from both games. They nearly pulled off an improbable upset against top-ranked Alabama two weeks ago, easily covering the 21-point spread.

Texas looked as if it was going to fall victim to a trap game last week, as UTSA took a 17-7 lead in the second quarter. The Longhorns responded by scoring 34 of the next 37 points in a 41-20 win, covering the spread as 13-point favorites. Junior running back Bijan Robinson rushed for 183 yards and three touchdowns against UTSA, averaging 9.2 yards per carry.

Robinson is facing a Texas Tech defense that is coming off consecutive games against ranked opponents, allowing at least 27 points in both contests. SportsLine's model has Robinson rushing for more than 110 yards and a touchdown on Saturday afternoon, which is one reason why Texas is covering the spread in almost 60% of simulations.'

Another one of the model's college football picks: No. 7 USC (-6) goes on the road and covers against Oregon State in a 9:30 p.m. ET matchup in Corvallis. USC's offense is clicking on all cylinders already, scoring 40-plus points in all three of its games this season. The Trojans are led by sophomore quarterback Caleb Williams, who has completed 74.4% of his passes for 874 yards and eight touchdowns.

Oregon State's defense has looked shaky at times early in the year, giving up 28 points to Montana State and 32 points to Fresno State. The Beavers are going to have trouble matching the Trojans blow for blow on Saturday night. SportsLine's model is expecting another big day from Williams, as he is throwing for more than 320 yards and three touchdowns in the latest simulations.

Oregon State quarterback Chance Nolan is not having nearly as much success in the simulations, completing just 16 of 26 passes for less than 240 yards and an interception. The Trojans are one of the strongest picks of the week, covering the spread in more than 70% of simulations.'See which other teams the model likes here.

The model has also made the call on who wins and covers in every other FBS matchup in Week 4, and it says a Top 25 favorite will go down hard in one of the week's biggest games.'You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $3,300 in profit over the past six-plus seasons, and find out.

See full Week 4 college football picks, odds, predictions here

Friday, Sept. 23

Virginia at Syracuse (-10, 53)

Syracuse Orange vs. Virginia Cavaliers Moneyline Spread Total CUSE -365 BET NOW -10 -110 BET NOW o53 -110 BET NOW UVA +285 BET NOW +10 -110 BET NOW u53 -110 BET NOW

Nevada at Air Force (-24, 46.5)

Air Force Falcons vs. Nevada Wolf Pack Moneyline Spread Total AF -4000 BET NOW -24 -110 BET NOW o46.5 -110 BET NOW NEVADA +1450 BET NOW +24 -110 BET NOW u46.5 -110 BET NOW

Boise State at UTEP (+16, 45.5)

UTEP Miners vs. Boise State Broncos Moneyline Spread Total UTEP +500 BET NOW +16 -110 BET NOW o45.5 -110 BET NOW BOISE -700 BET NOW -16 -110 BET NOW u45.5 -110 BET NOW

Saturday, Sept. 24

Kent State at Georgia (-45, 62)

Maryland at Michigan (-17, 64.5)

Michigan Wolverines vs. Maryland Terrapins Moneyline Spread Total MICH -700 BET NOW -17 -110 BET NOW o64.5 -110 BET NOW MD +500 BET NOW +17 -110 BET NOW u64.5 -110 BET NOW

Central Michigan at Penn State (-28, 63.5)

Penn State Nittany Lions vs. Central Michigan Chippewas Moneyline Spread Total PSU -7000 BET NOW -28 -110 BET NOW o63.5 -110 BET NOW CMICH +1800 BET NOW +28 -110 BET NOW u63.5 -110 BET NOW

Duke at Kansas (-7, 65.5)

Kansas Jayhawks vs. Duke Blue Devils Moneyline Spread Total KANSAS -285 BET NOW -7 -110 BET NOW o65.5 -110 BET NOW DUKE +228 BET NOW +7 -110 BET NOW u65.5 -110 BET NOW

Clemson at Wake Forest (+7, 55.5)

Wake Forest Demon Deacons vs. Clemson Tigers Moneyline Spread Total WAKE +228 BET NOW +7 -110 BET NOW o55.5 -110 BET NOW CLEM -285 BET NOW -7 -110 BET NOW u55.5 -110 BET NOW

Baylor at Iowa State (-2.5, 45.5)

Iowa State Cyclones vs. Baylor Bears Moneyline Spread Total IOWAST -135 BET NOW -2.5 -110 BET NOW o45.5 -110 BET NOW BAYLOR +115 BET NOW +2.5 -110 BET NOW u45.5 -110 BET NOW

Florida at Tennessee (-10.5, 62.5)

Tennessee Volunteers vs. Florida Gators Moneyline Spread Total TENN -355 BET NOW -10.5 -110 BET NOW o62.5 -110 BET NOW FLA +278 BET NOW +10.5 -110 BET NOW u62.5 -110 BET NOW

Notre Dame at North Carolina (-1.5, 55)

North Carolina Tar Heels vs. Notre Dame Fighting Irish Moneyline Spread Total UNC -125 BET NOW -1.5 -110 BET NOW o55 -110 BET NOW ND +105 BET NOW +1.5 -110 BET NOW u55 -110 BET NOW

Texas at Texas Tech (+7, 61)

Texas Tech Red Raiders vs. Texas Longhorns Moneyline Spread Total TXTECH +228 BET NOW +7 -110 BET NOW o61 -110 BET NOW TEXAS -285 BET NOW -7 -110 BET NOW u61 -110 BET NOW

Tulsa at Ole Miss (-21.5, 65.5)

Ole Miss Rebels vs. Tulsa Golden Hurricane Moneyline Spread Total MISS -1700 BET NOW -21.5 -110 BET NOW o65.5 -110 BET NOW TULSA +950 BET NOW +21.5 -110 BET NOW u65.5 -110 BET NOW

Oregon at Washington State (+6.5, 57.5)

Washington State Cougars vs. Oregon Ducks Moneyline Spread Total WASHST +205 BET NOW +6.5 -105 BET NOW o57.5 -110 BET NOW OREG -250 BET NOW -6.5 -115 BET NOW u57.5 -110 BET NOW

Northern Illinois at Kentucky (-26.5, 53)

Kentucky Wildcats vs. Northern Illinois Huskies Moneyline Spread Total UK -4500 BET NOW -26.5 -110 BET NOW o53 -110 BET NOW NILL +1550 BET NOW +26.5 -110 BET NOW u53 -110 BET NOW

Arkansas at Texas A&M (-2, 48.5)

Texas A&M Aggies vs. Arkansas Razorbacks Moneyline Spread Total TXAM -130 BET NOW -2 -110 BET NOW o48.5 -110 BET NOW ARK +110 BET NOW +2 -110 BET NOW u48.5 -110 BET NOW

Wisconsin at Ohio State (-19, 57)

Ohio State Buckeyes vs. Wisconsin Badgers Moneyline Spread Total OHIOST -1100 BET NOW -19 -110 BET NOW o57 -110 BET NOW WISC +700 BET NOW +19 -110 BET NOW u57 -110 BET NOW

Vanderbilt at Alabama (-40.5, 59)

Kansas State at Oklahoma (-12.5, 53)

Oklahoma Sooners vs. Kansas State Wildcats Moneyline Spread Total OKLA -480 BET NOW -12.5 -110 BET NOW o53 -110 BET NOW KSTATE +360 BET NOW +12.5 -110 BET NOW u53 -110 BET NOW

USC at Oregon State (+6, 70.5)

Oregon State Beavers vs. USC Trojans Moneyline Spread Total OREGST +180 BET NOW +6 -110 BET NOW o70.5 -110 BET NOW USC -220 BET NOW -6 -110 BET NOW u70.5 -110 BET NOW

Utah at Arizona State (+15.5, 54)

Arizona State Sun Devils vs. Utah Utes Moneyline Spread Total ARIZST +460 BET NOW +15.5 -110 BET NOW o54 -110 BET NOW UTAH -650 BET NOW -15.5 -110 BET NOW u54 -110 BET NOW

Stanford at Washington (-13.5, 63.5)

Washington Huskies vs. Stanford Cardinal Moneyline Spread Total WASH -550 BET NOW -13.5 -110 BET NOW o63.5 -110 BET NOW STNFRD +400 BET NOW +13.5 -110 BET NOW u63.5 -110 BET NOW
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