Louisville vs. South Florida odds, line: 2022 college football picks, Week 4 predictions from proven model

Fri, Sep 23, 2022
NCAAF News (AP)

Louisville vs. South Florida odds, line: 2022 college football picks, Week 4 predictions from proven model

The Louisville Cardinals and South Florida Bulls will both be looking to get back to the .500 mark on the season when they square off on Saturday. Louisville had a chance to win its game on the final drive against Florida State last week, but an interception doomed the Cardinals in a 35-31 final. South Florida nearly sprung a major upset at'Florida before botching a late field goal try.'

Kickoff is set for noon ET. The Cardinals are favored by 14.5 points in the latest Louisville vs. South Florida odds from Caesars Sportsbook, while the over/under is set at 64.5. Before entering any South Florida vs. Louisville picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. South Florida. You can head to SportsLine to see its picks. Here are several college football odds for Louisville vs. South Florida:

  • Louisville vs. USF spread: Louisville -14.5
  • Louisville vs. USF over/under: 64.5 points
  • Louisville vs. USF picks: See picks here
Louisville Cardinals vs. South Florida Bulls Moneyline Spread Total LVILLE -600 BET NOW -14.5 -110 BET NOW o64.5 -110 BET NOW SFLA +430 BET NOW +14.5 -110 BET NOW u64.5 -110 BET NOW

Louisville will be at home for the second consecutive week after playing a pair of road games to open the season. The Cardinals are also playing on an extra day of rest following their loss to Florida State last week, making this a strong scheduling spot. They held a 31-28 lead in the fourth quarter before allowing the Seminoles to score the game's final touchdown. Louisville quarterback Malik Cunningham has not lived up to expectations so far this season, but the senior should start to turn things around.'

He threw for nearly 3,000 yards and 19 touchdowns last year, while also rushing for more than 1,000 yards. Cunningham threw for 243 yards and rushed for 127 against Florida State last week, and he will be facing a less-talented defense this week. USF is on a 10-game road losing streak and has only won once in its last eight games overall.'

South Florida has shown huge signs of improvement this season, particularly with its performance last week. The Bulls notched a 42-20 win over Howard in Week 2 before nearly taking down a ranked Florida team on the road. They had a chance to tie the game in the final moments, but a botched field goal attempt was the final blow.'

Regardless, South Florida is going to bring a new level of confidence into this road game. The Bulls have also scored 20-plus points in all three of their games, which is not something that Louisville can claim. In addition, Louisville has won and covered just once in its last five games.

The model has simulated South Florida vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. South Florida? And which side of the spread hits in nearly 60% of simulations?'Visit SportsLine now to find out which side of the South Florida vs. Louisville spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.

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