San Francisco 49ers vs. Indianapolis Colts Betting Trends

SPREAD

TOTAL

-246

-6
(+106)

O 46
(-114)

+209

+6
(-120)

U 46
(-102)

NFL

8:15 PM ET (12/22/2025)

49ers vs. Colts Betting Odds, Free Picks, and Predictions - 8:15 PM ET (Mon, Dec 22, 2025) Tue, Dec 16, 2025 NFL News (CapperTek)
Colts vs. Seahawks Betting Odds, Free Picks, and Predictions - 4:25 PM ET (Sun, Dec 14, 2025) Mon, Dec 8, 2025 NFL News (CapperTek)
Titans vs. 49ers Betting Odds, Free Picks, and Predictions - 4:25 PM ET (Sun, Dec 14, 2025) Mon, Dec 8, 2025 NFL News (CapperTek)
Colts vs. Jaguars Betting Odds, Free Picks, and Predictions - 1:00 PM ET (Sun, Dec 7, 2025) Mon, Dec 1, 2025 NFL News (CapperTek)